Elsewhere, Alan MacDonald will play his first league match this season after being selected at openside flanker and Matt Mustchin is restored to the second row. Simon Cross could also make his first appearance for Edinburgh since April, after recovering from a thumb fracture to start on the bench. Craig Smith has also been named among the replacements after his recent calf injury.
Lynn Howells said: "We've made the changes because of the calibre of the side we're playing, and those players coming in give strength in certain areas that we'll need against Munster. Dave Callam has played a lot of league rugby and has proved himself at this level, so he now has an opportunity while Allister Hogg is injured.
"We've decided to rest Ross Rennie as he's played five Magners League games in a row and he's only a young player. That gives us an opportunity to see Alan MacDonald who, again, has proved he has the capabilities to play at this level. If we are to progress throughout the season, we need as many players having game time as we can manage, without weakening the team.
"As far as Edinburgh is concerned, this is probably the best game we could have before we go into the Heineken Cup, playing the current European champions. It gives the squad an opportunity to play at the highest level before we face Agen next week."
Unavailable due to injury: Matt Dey (calf), Allister Hogg (elbow), Simon Taylor (knee).
Edinburgh team to play Munster at Thomond Park, Friday 29 September, kick-off 7.30pm
15 Hugo Southwell
14 Chris Paterson (captain)
13 Marcus Di Rollo
12 Rob Dewey
11 Simon Webster
10 Phil Godman
9 Mike Blair *
1 Allan Jacobsen
2 Dougie Hall
3 Alasdair Dickinson *
4 Matt Mustchin
5 Scott Murray
6 Alasdair Strokosch *
8 David Callam *
7 Alan MacDonald *
Substitutes
16 Andrew Kelly *
17 Craig Smith
18 Dave Hewett
19 Fergus Pringle
20 Greig Laidlaw
21 Simon Cross
22 Duncan Hodge
* Member of the Scottish Institute of Sport
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