There are four changes in the pack while in the backline Matthew Watkin's inclusion at inside centre sees Gavin Evans move to the bench.
In the boilerhouse Deacon Manu swaps places with Craig Dunlea from the bench, while Vernon Cooper replaces Inoke Afeaki at lock.
In the back row James Bater and Nathan Thomas replace Gavin Thomas and Alix Popham respectively.
Scarlets captain Dwayne Peel is hoping his side can bounce back from the 50-24 defeat to the Ospreys.
"We were disappointed with that result and some areas of our performance," he said.
"There's no hiding from that. We probably weren't where we should have been and we need to step up across the board.
"But it's only one game we've played poorly. The boys have drawn a line under that.
"We'll learn our lessons, but we have to move on from it. Monday is a big challenge again.
"There should be another big crowd at the Arms Park and the atmosphere is outstanding when these derby games come along."
15 Barry Davies
14 Dafydd James
13 Regan King
12 Matthew Watkins
11 Mark Jones
10 Ceiron Thomas
9 Dwayne Peel (capt);
1 Iestyn Thomas
2 Matthew Rees
3 Deacon Manu
4 Vernon Cooper
5 Scott MacLeod
6 Dafydd Jones
7 James Bater
8 Nathan Thomas
16 Craig Dunlea 17 Ken Owens 18 Adam Jones 19 Alix Popham 20 Clive Stuart-Smith 21 Gavin Evans 22 Darren Daniel
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