Davies will be the second player to reach the milestone, following in the footsteps of second row Adam Jones. The ex-Wales front rower is one of five changes to the pack which brushed aside Munster last Friday in the Heineken Cup quarter-final.
Loose-head Phil John gets his first league start since September while Adam Jones returns to the second row in place of Vernon Cooper who is nursing sore ribs.
James Bater and Dafydd Jones replace Gavin Thomas and Alix Popham respectively in the back row.
There is only one change to the backline, where Matthew Watkins comes in for Regan King at outside centre, with the Kiwi dropping to the bench.
Scarlets Team:
15 Barry Davies
14 Dafydd James
13 Matthew Watkins
12 Gavin Evans
11 Mark Jones
10 Stephen Jones
9 Dwayne Peel;
1 Phil John
2 Matthew Rees
3 John Davies
4 Adam Jones
5 Scott MacLeod
6 Simon Easterby (capt)
7 James Bater
8 Dafydd Jones
16 Deacon Manu 17 Ken Owens 18 Inoke Afeaki 19 Alix Popham 20 Liam Davies 21 Ceiron Thomas 22 Regan King
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