O’Driscoll, who has recovered from a hamstring injury, is the only change coach Eddie O'Sullivan has made to the Irish team; his fellow centre, Gordon D’Arcy, is still unavailable.
IRELAND
15 Geordan Murphy (Leicester), 14 Girvan Dempsey (Leinster), 13 Brian O'Driscoll (Leinster), 12 Shane Horgan (Leinster), 11 Denis Hickie (Leinster), 10 Ronan O’Gara (Munster), 9 Peter Stringer (Munster), 1 Reggie Corrigan (Leinster), 2 Shane Byrne (Leinster), 3 John Hayes (Munster), 4 Malcolm O’Kelly (Leinster), 5 Paul O’Connell (Munster), 6 Simon Easterby (Llanelli), 7 Johnny O’Connor (Wasps), 8 Anthony Foley
(Munster).
Replacements: 16 Frank Sheahan (Munster), 17 Marcus Horan (Munster), 18 Donncha O’Callaghan (Munster), 19 Eric Miller (Leinster), 20 Guy Easterby (Leinster), 21 David Humphreys (Ulster), 22 Kevin Maggs (Ulster).
Meanwhile England head coach Andy Robinson has made one change to his starting line up and three on the bench.
Bath prop Matt Stevens will make his debut at tight head prop in place of the injured Phil Vickery, whilst team mate Duncan Bell, along with Leicester pair Andy Goode and Ollie Smith, are the changes on the bench.
Speaking of his selection Robinson said: " All three players have shown outstanding form of late, most recently in the England A win against France A and for their club. Selection beckons when players demonstrate such consistent ability.
"This game against Ireland will be massive. We recognise it's a must-win game for us this season."
ENGLAND
15 Jason Robinson Capt (Sale Sharks), 14 Mark Cueto (Sale Sharks) , 13 Jamie Noon (Newcastle Falcons) , 12 Olly Barkley (Bath), 11 Josh Lewsey (London Wasps), 10 Charlie Hodgson (Sale Sharks), 9 Harry Ellis (Leicester Tigers), 1 Graham Rowntree (Leicester Tigers), 2 Steve Thompson (Northampton Saints), 3 Matt Stevens (Bath), 4 Danny Grewcock (Bath), 5 Ben Kay (Leicester Tigers), 6 Joe Worsley (London Wasps), 7 Lewis Moody (Leicester Tigers), 8 Martin Corry (Leicester Tigers).
Replacements: 16 Andy Titterrell (Sale Sharks), 17 Duncan Bell (Bath), 18 Steve Borthwick (Bath), 19 Andy Hazell (Gloucester), 20 Matt Dawson (London Wasps), 21 Andy Goode (Leicester Tigers), 22 Ollie Smith (Leicester Tigers).
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