Wales internationals Nick Robinson, John Yapp and Robert Sidoli come into the team and Nick Macleod returns to Full Back.
New recruits Andy Powell and Mike Phillips will also make their competitive debuts for the team at Galway Sportsground, having both featured in last weekend's friendly against Bristol.
Team:
Nick Macleod, Chris Czekaj, Rhys Williams (C), Tristan Davies, Craig Morgan, Nicky Robinson, Mike Phillips
John Yapp, Gareth Williams, Martin Jones, Deiniol Jones, Robert Sidoli, Maama Molitika, Andy Powell, Robin Sowden-Taylor
Replacements
Ryan Powell, Lee Thomas, Matthew Nuthall, Ben Evans, Rhys Thomas, Craig Quinnell, Mark Lewis
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