Ospreys won 31-10 in the Magners League when the two teams met on 4 October and have not achieved a seasons double over the Scotsmen since 2006/07.
Edinburgh have won just one of their most recent four games in the Magners League: 21-12 at home to Cardiff Blues on 9 January. Edinburgh have won their last two matches against the Welsh regions.
Ospreys currently sit atop the Magners League table following four straight victories, whilst they have won just one away game in the Magners League since September: 21-14 at Scarlets on Boxing Day.
Referee: George Clancy (IRFU, 35th League game).
Assistant Referees: David Changleng (SRU), Bob Nevans (SRU).
TMO: Iain Ramage (SRU).
Live S4/C